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Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 443-446 doi: 10.1007/s11684-009-0079-5
Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang
《医学前沿(英文)》 2019年 第13卷 第1期 页码 104-111 doi: 10.1007/s11684-017-0568-x
关键词: retinol dehydrogenase 13 carbon tetrachloride acute liver injury Cyp2e1 Spot14
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 46-56 doi: 10.1007/s11684-015-0375-1
Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vaso-occlusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is increasingly recognized as an important intermediate in these pathophysiological processes and is therefore an important target for therapeutic intervention. The transcription factor nuclear erythroid derived- 2 related factor 2 (Nrf2) controls the expression of anti-oxidant enzymes and is emerging as a protein whose function can be exploited with therapeutic intent. This review article is focused on triterpenoids that activate Nrf2, and their potential for reducing oxidative stress in SCD as an approach to prevent organ dysfunction associated with this disease. A brief overview of oxidative stress in the clinical context of SCD is accompanied by a discussion of several pathophysiological mechanisms contributing to oxidative stress. Finally, these mechanisms are then related to current management strategies in SCD that are either utilized currently or under evaluation. The article concludes with a perspective on the potential of the various therapeutic interventions to reduce oxidative stress and morbidity associated with SCD.
关键词: oxidative stress Nrf2 triterpenoids sickle cell disease vaso-occlusion CDDO-Me
Yu Yang, Hassan Javed, Danning Zhang, Deyi Li, Roopa Kamath, Kevin McVey, Kanwartej Sra, Pedro J.J.
《化学科学与工程前沿(英文)》 2017年 第11卷 第3期 页码 387-394 doi: 10.1007/s11705-017-1657-8
关键词: TiO2 pretreatment bioremediation total petroleum hydrocarbons ultraviolet
Cyanobacterial photo-driven mixotrophic metabolism and its advantages for biosynthesis
Ni Wan,Mary Abernathy,Joseph Kuo-Hsiang Tang,Yinjie J. Tang,Le You
《化学科学与工程前沿(英文)》 2015年 第9卷 第3期 页码 308-316 doi: 10.1007/s11705-015-1521-7
关键词: CO2 mass transfer N2 fixation photosystem RuBisCO the TCA cycle
Xiying Hao, Francis J. Larney
《环境科学与工程前沿(英文)》 2017年 第11卷 第3期 doi: 10.1007/s11783-017-0955-1
关键词: Livestock manure greenhouse gas flux straw bale compost bin N2O CH4 CO2
Techno-economic assessment of pulverized coal boilers and IGCC power plants with CO 2 capture
HEWITT, J. MONDOL, A. MINCHENER,
《化学科学与工程前沿(英文)》 2010年 第4卷 第2期 页码 196-206 doi: 10.1007/s11705-009-0237-y
关键词: breakeven electricity ECLIPSE technical performance appropriate economic
Two-dimensional SnS2 nanosheets on Prussian blue template for high performance sodium ion batteries
Glenn J. Sim, Kakui Ma, Zhixiang Huang, Shaozhuan Huang, Ye Wang, Huiying Yang
《化学科学与工程前沿(英文)》 2019年 第13卷 第3期 页码 493-500 doi: 10.1007/s11705-019-1826-z
关键词: Prussian blue carbon nanocubes tin disulfide sodium ion batteries
Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott
《化学科学与工程前沿(英文)》 2016年 第10卷 第2期 页码 186-195 doi: 10.1007/s11705-015-1540-4
关键词: RNA splicing gene expression breast cancer DNA damage CHK1
Plasma-catalysis: Is it just a question of scale?
J. Christopher Whitehead
《化学科学与工程前沿(英文)》 2019年 第13卷 第2期 页码 264-273 doi: 10.1007/s11705-019-1794-3
关键词: plasma catalysis plasma-activated catalysis non-thermal plasma CO2 conversion
Carbon dioxide: a renewable feedstock for the synthesis of fine and bulk chemicals
PATIL, Pawan J. TAMBADE, Sachin R. JAGTAP, Bhalchandra M. BHANAGE,
《化学科学与工程前沿(英文)》 2010年 第4卷 第2期 页码 213-235 doi: 10.1007/s11705-009-0227-0
关键词: inertness CO phosgene-based synthetic quinazoline-2 4 equilibrium
标题 作者 时间 类型 操作
Effect of atorvastatin on tumor growth and metastasis in a breast cancer cell xenograft model and its mechanism
Liu LIU MD, PhD, Yaogui NING MM, Chen CHEN MD, Daowen WANG MD, PhD,
期刊论文
Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spot14 and Cyp2e1 expression
Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang
期刊论文
第三届环境、工业和能源工程国际会议(EI2E 2019)
2019年09月19日
会议信息
Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review
null
期刊论文
Merits and limitations of TiO
Yu Yang, Hassan Javed, Danning Zhang, Deyi Li, Roopa Kamath, Kevin McVey, Kanwartej Sra, Pedro J.J.
期刊论文
Cyanobacterial photo-driven mixotrophic metabolism and its advantages for biosynthesis
Ni Wan,Mary Abernathy,Joseph Kuo-Hsiang Tang,Yinjie J. Tang,Le You
期刊论文
Greenhouse gas emissions during co-composting of cattle feedlot manure with construction and demolition (C&D) waste
Xiying Hao, Francis J. Larney
期刊论文
Techno-economic assessment of pulverized coal boilers and IGCC power plants with CO 2 capture
HEWITT, J. MONDOL, A. MINCHENER,
期刊论文
Two-dimensional SnS2 nanosheets on Prussian blue template for high performance sodium ion batteries
Glenn J. Sim, Kakui Ma, Zhixiang Huang, Shaozhuan Huang, Ye Wang, Huiying Yang
期刊论文
第四届设计、机械和材料工程国际会议(D2ME 2019)
2019年09月26日
会议信息
Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive
Andrew Best,Katherine James,Gerald Hysenaj,Alison Tyson-Capper,David J. Elliott
期刊论文
肖永红:临床高耐药与高毒性病原体共进化(2023年2月22日)
2023年03月10日
会议视频